Bhargy Sharma, PhD

* Corresponding author ; # Equal contribution

Patents

• (2025) US Application US18/778,525. Konstantin Pervushin, Jia Yi Kimberly Low, Jodhbir Singh Mehta, Bhargy Sharma. Novel lipocalin-type prostaglandin d synthase (L-pgds) mutant and uses thereof. Published US20250027071A1.

 

Research articles

• (2025) Pazhanichamy Kalailingam,  SoFong Cam Ngan,  Ranjith Iyappan,  Afra Nehchiri,  Khalilatul-Hanisah Mohd-Kahliab,  Benjamin Sian Teck Lee,  Bhargy Sharma,  Radek Machan,  Sint Thida Bo,  Emma S. Chambers,  Val A. Fajardo,  Rebecca E. K. Macpherson,  Jian Liu,  Panagiota Klentrou,  Evangelia Litsa Tsiani,  Kah Leong Lim,  I. Hsin Su,  Yong-Gui Gao,  A. Mark Richar,  Raj N. Kalaria,  Christopher P. Chen,  Cynthia Balion,  Dominique de Kleijn,  Neil E. McCarthy,  Siu Kwan Sze. Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation. Aging Cell, 00, e14425.

• (2024) Bandaru, Shamili; George, Nilja; Sharma, Bhargy; Palanivel, Mathangi; WU, Wen-Ya; Ghosh, Krishna; Ball, Writoban; Zoltán Gulyás, Balázs; Padmanabhan, Parasuraman*; Ghosh, Siddhartha; Chakrabortty, Sabyasachi*. Aqueous Based Ultra-Small Diluted Magnetic Semiconductors as a Potential Dual Imaging Probe in Biomedicine. Biomaterials Science, 12, 6338-6350. 

• (2024) Rinku Saran, ‪Maciej Klein, Bhargy Sharma, Jun Jie Loke, Quentin Moana Perrin, Ali Miserez*. Proton Conductivity of the Protein-based Velvet Worm Slime. iScience; 110216.‬‬‬‬‬‬‬‬‬‬

• (2024) Kai Ye#, Sze Yuet Chin#, Bhargy Sharma*, Yunpeng Lu, Nichole Lin Xi, Kai Xue*. Characterizing the Behaviour of Water Interacting with a Nano-Pore Material: A Structural Investigation in Native Environment Using Magnetic Resonance Approaches. ChemPhysChem; e202400053. 

• (2023) Pazhanichamy Kalailingam, Khalilatul-Hanisah Mohd-Kahliab, SoFong Cam Ngan, Ranjith Iyappan, Evelin Melekh, Tian Lu, Gan Wei Zien, Bhargy Sharma, Tiannan Guo, Adam J MacNeil, Rebecca EK MacPherson, Evangelia Litsa Tsiani, Deborah D O'Leary, Kah Leong Lim, I Hsin Su, Yong-Gui Gao, A Mark Richards, Raj N Kalaria, Christopher P Chen, Neil E McCarthy, Siu Kwan Sze*. Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation. EMBO Mol Med; 15: e18526.

• (2022) Yang Lu#, Bhargy Sharma#, Wei Long Soon, Xiangyan Shi, Tianyun Zhao, Yan Ting Lim, Radoslaw Sobota, Shawn Hoon, Giovanni Pilloni, Adam Usadi, Konstantin Pervushin and Ali Miserez*. Complete sequences of the velvet worm slime proteins reveal that slime formation is enabled by disulfide bonds and intrinsically disordered regions. Advanced Science; 2201444 (#Co-first authors).​

• (2021) Sharma, B., Grandjean, J., Phillips, M., Kumar, A., Mandino, F., Yeow, L.Y., Nandwana, V., Dravid, V.P., Bengang, X., Lim, S. and Pervushin, K.*. Lipocalin-Type Prostaglandin D Synthase conjugates as magnetic resonance imaging contrast agents for detecting Amyloid β-rich regions in the brain of live Alzheimer's Disease mice. Advanced NanoBiomed Research; 2100019.

• (2021) Ambrish Kumar, Vikas Nandwana, Soo-Ryoon Ryoo, Samyukta Ravishankar, Bhargy Sharma, Konstantin Pervushin, Vinayak P. Dravid, Sierin Lim*. Magnetoferritin enhances T2 contrast magnetic resonance imaging of macrophages. Materials Science and Engineering: C; 112282.

• ​(2019) Kannaian B, Sharma B, Phillips M, Chowdhury A, Manimekalai MSS, Adav SS, Ng JTY, Kumar A, Lim S, Mu Y, Sze SK, Gerhard Grüber G, and Pervushin K*. Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils. Scientific Reports; 9(1):1-17.​

• (2017) Bao Q., Morshedi A, Wang F, Sharma B, Pervushin K, Yu W-P, Peter Dröge*. Utf1 contributes to intergenerational epigenetic inheritance of pluripotency. Scientific Reports; 7:14612.​

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Review articles

• (2020) Bhargy Sharma* & Konstantin Pervushin*. Magnetic Nanoparticles as In Vivo Tracers for Alzheimer’s Disease. Magnetochemistry; 6(1):13. {Invited review}

• (2016) N. Thushara Vijayakumar, Amit Sangwan, Bhargy Sharma, Arshad Majid and Rajanikant G K*. Cerebral ischemic preconditioning: The road so far… Molecular Neurobiology; 53:2579–2593.

• (2014) Pradeep H., Bhargy Sharma, Rajanikant G K*. Drp1 in ischemic neuronal death: An unusual suspect. Current Medicinal Chemistry; 21(19):2183-9.

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Book chapters

• (2023) Ambrish Kumar, Bhargy Sharma & Sierin Lim*. Protein Cage Relaxivity Measurement for Magnetic Resonance Imaging Contrast Agents. In: Ueno, T., Lim, S., Xia, K. (eds) Protein Cages. Methods in Molecular Biology, vol 2671. Humana, New York, NY. {Invited chapter}

• (2019) Bhargy Sharma and Konstantin Pervushin*. Neuroprotective Function of Non-Proteolytic Amyloid-β Chaperones in Alzheimer’s Disease. Ed. Dmitry Kurouski. Amyloid Diseases, IntechOpen. {Invited Chapter}